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Abstract #1612

Robust Fat Suppression for High-Resolution Diffusion-Weighted Imaging

Joelle E. Sarlls1,2, Wen-Ming Luh3, Carlo Pierpaoli1

1NICHD, National Institutes of Health, Bethesda, MD, United States; 2Henry M. Jackson Foundation, Rockville, MD, United States; 3NIMH, National Institutes of Health, Bethesda, MD, United States

Although spectral-spatial excitation pulses provide single-shot EPI diffusion-weighted images without signal from fat, they are limited in the attainable minimum slice thickness. To achieve higher resolution, traditional fat supression methods must be used. In this work, an exhaustive investigation was performed to determine which, if any, implementation of the slice-selective gradient reversal method completely supressed the fat signal. The dual-spin-echo diffusion preparation implementation, with opposite polarity slice-select gradients for the two 180 refocusing pulses, combined with traditional fat supression was found to completely suppress fat in phantoms and in vivo.