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Abstract #1633

Measuring Isotropic Diffusion with Rotating Diffusion Gradients

Irvin Teh1,2, Xavier Golay1,3, David Larkman2

1Lab of Molecular Imaging, Singapore Bioimaging Consortium, Singapore, Singapore; 2Imaging Sciences Department, Imperial College London, London, United Kingdom; 3Institute of Neurology, University College London, London, United Kingdom

A diffusion-weighted fast spin echo periodically rotated overlapping parallel lines with enhanced reconstruction (DW-FSE-PROPELLER) sequence was combined with a multiple axis Stejskal-Tanner diffusion weighting scheme that rotated and alternated across blades. This reduced the number of DW acquisitions needed to acquire the mean apparent diffusion coefficient from three to one, halving the total acquisition time. This motion and distortion robust method was tested in the in-vivo mouse brain and compared to previously proposed rotating DW strategies.