Repeatability of Mono- And Bi-Exponentially Modelled Diffusion at 3 Tesla

Peter Gibbs¹, Martin D. Pickles¹, Lindsay W. Turnbull¹

Recent work has demonstrated that it is technically possible to acquire DWI data with low b-values to quantify the perfusive fraction of the ADC decay curve via bi-exponential modelling. This work seeks to assess the repeatability of such modelling and the dependence on accurate b-value implementation by system manufacturers. A repeatability of 21% for mono-exponential fitting indicates its efficacy for monitoring treatment induced changes. Bi-exponential fitting is found to be less repeatable, especially the perfusive fraction parameter.