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Abstract #1651

Repeatability of Mono- And Bi-Exponentially Modelled Diffusion at 3 Tesla

Peter Gibbs1, Martin D. Pickles1, Lindsay W. Turnbull1

1Centre for MR Investigations, University of Hull, Hull, East Yorkshire, United Kingdom

Recent work has demonstrated that it is technically possible to acquire DWI data with low b-values to quantify the perfusive fraction of the ADC decay curve via bi-exponential modelling. This work seeks to assess the repeatability of such modelling and the dependence on accurate b-value implementation by system manufacturers. A repeatability of 21% for mono-exponential fitting indicates its efficacy for monitoring treatment induced changes. Bi-exponential fitting is found to be less repeatable, especially the perfusive fraction parameter.