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Abstract #1655

Language Lateralization Explained by the Generalized Fractional Anisotropy in the Auditory Nerve and the Corpus Collosum as Studied Using Diffusion Spectrum Imaging Tractography and FMRI

Kayako Matsuo1, Yu-Chun Lo2, Fang-Cheng Yeh3, Yi-Huan Wu4, Shen-Hsing Annabel Chen5, Wen-Yih Isaac Tseng1

1Center for Optoelectronic Biomedicine, National Taiwan University College of Medicine, Taipei, Taiwan; 2Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan; 3Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, United States; 4Department of Medicine, National Taiwan University, Taipei, Taiwan; 5Division of Psychology, School of Humanities and Social Sciences, Nanyang Technological University, Singapore

We measured the generalized fractional anisotropy (GFA) of the auditory nerve (AN) to bilateral Heschl's gyri via the corpus callosum (CC) using diffusion spectrum imaging (DSI). The individual language asymmetry was determined using fMRI. The left lateralized AN was found to be related to the leftward language asymmetry. The mild lateralization in the AN as well as the lower GFA in the CC tend to have relationship with the bilateral language function. The findings provide plausible evidence for the degree of conductivity of the AN as well as the CC in determining language lateralization/asymmetry between the hemispheres.