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Abstract #1685

On the Behavior of DTI and Q-Ball Derived Anisotropy Indices

Klaus H. Fritzsche1, Bram Stieltjes2, Frederik B. Laun3, Hans-Peter Meinzer1

1Division of Medical and Biological Informatics, German Cancer Research Center, Heidelberg, B-W, Germany; 2Division of Radiology, German Cancer Research Center; 3Division of Medical Physics, German Cancer Research Center

Anisotropy indices in diffusion imaging have never been systematically analyzed under conditions of heterogeneous fiber configurations. Furthermore, q-ball imaging indices have so far not been evaluated with respect to accuracy, precision, b-value dependency and contrast-to-noise ratio (CNR). This study performed a systematic analysis using Monte Carlo simulations and measurements in crossing fiber phantoms. The GFA (reconstructed with solid angle consideration) showed the lowest dependency on b-value and the best results regarding accuracy and precision. Its behavior in crossing fiber voxels was also preferable. Main drawback was its low CNR, especially in low anisotropy fibers.