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Abstract #1687

A More Accurate and B-Value Independent Estimation of Diffusion Parameters Using Diffusion Kurtosis Imaging

Jelle Veraart1, Wim Van Hecke2,3, Dirk Poot1, Ines Blockx4, Annemie Van Der Linden4, Marleen Verhoye4, Jan Sijbers1

1Vision Lab, University of Antwerp, Antwerp, Belgium; 2Department of Radiology, Antwerp University Hospital, Antwerp, Belgium; 3Department of Radiology, University Hospitals of the Catholic University of Leuven, Leuven, Belgium; 4Bio Imaging Lab, University of Antwerp, Antwerp, Belgium

Due to the presence of complex cellular microstructures in the brains white matter, the diffusion weighted signal attenuation with respect to the b-value can not accurately be approximated by the monoexponential function assumed by DTI. Because of this, the estimation of the diffusion coefficient and the associated diffusion parameters depend on the b-value of the acquisition. The recently proposed higher order DKI model fits the signal attenuation more properly as a result of which, as demonstrated in this study, a more accurate estimation of the diffusion parameters is obtained. In addition the parameter estimation appears b-value independent.