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Abstract #1690

An Accelerated, Alternative Approach for Estimating Zero-Displacement Probability in Hybrid Diffusion Imaging

A P. Hosseinbor1, J O. Fleming2, Y-C Wu3, A A. Samsonov4, A L. Alexander

1Medical Physics, University of Wisconsin-Madison, Madison, WI, United States; 2Neurology, University of Wisconsin-Madison; 3Dartmouth College; 4Radiology, University of Wisconsin-Madison

In HYDI, Po is conventionally estimated by using signal measurements in all shells (Poall), which requires long scan time. However, the highest diffusion-weighting measurements are likely to contribute most heavily to restricted diffusion (RD) signal. Thus, an alternative, faster approach for characterizing RD would be to use signal measurements only in outermost shell (Poouter). In this work, we compare both Poall and Poouter approaches in NAWM from MS patients and WM in a control group. We show that both approaches yield similar statistical properties for characterizing RD, which suggests Poouter is both adequate and faster than using full q-space measurements.