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Abstract #1693

Diffusion Gradient Calibration Influences the Accuracy of Fibre Orientation Density Function Estimation: Validation by Efficiency Measure

Yuliya Kupriyanova1, Oleg Posnansky2, N. J. Shah2,3

1Medical Imaging Physics, Institute of Neuroscience and Medicine - 4, Forschungzentrum Juelich, Juelich, Germany; 2Medical Imaging Physics, Institute of Neuroscience and Medicine - 4 , Forschungzentrum Juelich, Juelich, Germany; 3Department of Neurology, Faculty of Medicine, RWTH Aachen University, Aachen, Germany

Imperfections in the diffusion-weighted (DW) gradients may cause errors in the estimation of diffusion parameters. We present results demonstrating the influence of these errors in the accuracy of fibre orientation density function (ODF) estimation. A DW gradient calibration scheme, used to mitigate DW gradient errors, is also described. We compared the reconstructed fibre ODFs from two datasets, acquired in vivo with and without the application of the calibration scheme and calculated the statistical efficiency of the unbiased fibre ODF estimators for these datasets. It is shown that the calibration procedure can significantly improve results of the fibre ODF estimation.