Comparison of ADC Values Using Pulsed Field Gradient and Correlation Time Diffusion Techniques in a Murine Model of Steatohepatitis at 11.7T

Stephan William Anderson¹, Jorge A. Soto¹, Holly N. Milch¹, Hernan Jara¹

The purpose of this study was to compare the ADC values obtained using pulsed field gradient (PFG) and correlation time diffusion (CT-D) techniques in a mouse model of steatohepatitis at 11.7T. C57BL/6 mice fed a methionine-deficient choline-deficient (MCD) diet to induce steatohepatitis were sacrificed intermittently throughout this period for ex vivo liver imaging. A comparison of the parametric maps and whole sample histograms generated by the PFG and CTD techniques shows excellent agreement between the two diffusion techniques. In all cases CT-D parametric maps had significantly higher SNR and the histogram width was narrower than those generated using PFG technique.