Stephan William Anderson1, Jorge A. Soto1, Holly N. Milch1, Hernan Jara1
The purpose of this study was to compare the ADC values obtained using pulsed field gradient (PFG) and correlation time diffusion (CT-D) techniques in a mouse model of steatohepatitis at 11.7T. C57BL/6 mice fed a methionine-deficient choline-deficient (MCD) diet to induce steatohepatitis were sacrificed intermittently throughout this period for ex vivo liver imaging. A comparison of the parametric maps and whole sample histograms generated by the PFG and CTD techniques shows excellent agreement between the two diffusion techniques. In all cases CT-D parametric maps had significantly higher SNR and the histogram width was narrower than those generated using PFG technique.