Kenneth K. Kwong1, Timothy G. Reese1, Koen Nelissen1, Ona Wu2, Suk-Tak Chan1, Benner Thomas1, Joseph B. Mandeville1, Mary Foley1, Wim Vanduffel1, David A. Chesler1
1MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States; 2MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital,, Charlestown, MA, United States
We investigated the feasibility of making relative cerebral blood flow (rCBF) maps from MR images acquired with short TR by measuring the initial rate of Gd-DTPA arriving within a time window smaller than the tissue mean transit time τ. We named this rCBF measurement technique utilizing the early data points of the bolus the early time points method (ET). ET offered rCBF results of reasonable gray-white flow contrast. Better brain coverage for ET can be obtained by applying the SIR-EPI technique. Attention was paid to the noise problem around the time of arrival (TOA) of the contrast agent.