Jehoon Yang1, Geun-Ho Im2,
Jae-Hun Kim1, Hyejung Heo2, Sera Yoon2,
Eunhee Cho2, Jaewon Lee2, Jung Hee Lee1
1Radiology, Sungkyunkwan University
School of Medicine, Seoul, Korea, Republic of; 2Center for
Molecualr and Cellular Imaging, Samsung Medical Center, Seoul, Korea,
Republic of
Converging
evidences have indicated that dynamic contrast-enhanced magnetic resonance
imaging (DCE-MRI) provides parameters indicating permeability of tumor
microvessels which has been shown to be closely related to angiogenesis.
Because endothelial cells are thought to be genetically stable compared with
tumor cells, tumor vasculature can be one of promising target for novel
anticancer agents. Therefore we designed this study to investigate the
anti-angiogenic inhibitory effect of KR-31831 that was newly developed for
anti-ischemic agent by our co-worker group on xenografted human ovarian
carcinoma model using DCE-MRI on a micro 7.0 Tesla MR system. Our preliminary
results suggest DEC-MRI may be useful tools to evaluate the anti-angiogenic
effect of KR-31831 on xenografted human ovarian carcinoma model.
Keywords