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Abstract #1768

Flow-Weighted Arterial Transit Time Mapping of the Human Brain

Toralf Mildner1, Stefan Hetzer1, Wolfgang Driesel1, Karsten Mller1, Harald E. Mller1

1NMR unit, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Saxony, Germany

Mapping of Arterial Transit times by Intravascular Signal SElection (MATISSE) was performed with and without a mild flow-weighting (FW). The arterial transit times, δa, of the flow-weighted data were increased on average by about 700 ms and the signal amplitudes roughly were halved. Flow-through signals, i. e. signals of arterial vessels permeating the voxel, are removed almost completely, although the MATISSE signal still is expected to be of vascular origin. The fact that δa with mild FW was found to be easily larger than 2 s might be important for the quantification of CBF in standard dual-coil CASL experiments.