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Abstract #1777

Comparing Kidney Perfusion Using Arterial Spin Labeling and Microsphere Methods in an Interventional Swine Model

Nathan S. Artz1, Andrew L. Wentland1, Elizabeth A. Sadowski2, Thomas M. Grist, 12, Arjang Djamali3, Sean B. Fain1,2

1Medical Physics, University of Wisconsin-Madison, Madison, WI, United States; 2Radiology, University of Wisconsin-Madison, Madison, WI, United States; 3Nephrology, University of Wisconsin-Madison, Madison, WI, United States

Two methods of measuring cortical kidney perfusion, fluorescent microspheres and ASL-FAIR, are compared for 11 swine each at four interventional time points: 1) under baseline conditions, 2) during an acetylcholine and fluid bolus challenge to increase perfusion, 3) initially after switching to isoflurane anesthesia , and 4) after two hours of isoflurane anesthesia. Across all swine, microspheres and ASL correlated (r = 0.72) and each technique tracked the expected perfusion changes due to the interventions, demonstrating statistical differences in perfusion (p < 0.05) between time points. In addition, ASL perfusion data was more consistent across swine. This data provides validation of ASL-FAIR for relative renal perfusion imaging, especially for evaluating time-averaged perfusion changes that may be observed in chronic disease.