Nathan S. Artz1, Andrew L. Wentland1,
Elizabeth A. Sadowski2, Thomas M. Grist, 12, Arjang
Djamali3, Sean B. Fain1,2
1Medical Physics, University of
Wisconsin-Madison, Madison, WI, United States; 2Radiology,
University of Wisconsin-Madison, Madison, WI, United States; 3Nephrology,
University of Wisconsin-Madison, Madison, WI, United States
Two
methods of measuring cortical kidney perfusion, fluorescent microspheres and
ASL-FAIR, are compared for 11 swine each at four interventional time points:
1) under baseline conditions, 2) during an acetylcholine and fluid bolus
challenge to increase perfusion, 3) initially after switching to isoflurane
anesthesia , and 4) after two hours of isoflurane anesthesia. Across all swine, microspheres and ASL correlated
(r = 0.72) and each technique tracked the expected perfusion changes due to
the interventions, demonstrating statistical differences in perfusion (p <
0.05) between time points. In
addition, ASL perfusion data was more consistent across swine. This data provides validation of ASL-FAIR for
relative renal perfusion imaging, especially for evaluating time-averaged
perfusion changes that may be observed in chronic disease.