Meaghan Anne O'Reilly1, Yuexi Huang1, Kullervo Hynynen1,2
1Imaging Research, Sunnybrook Research
Ultrasound monitoring of MR-guided transcranial ultrasound therapy could help identify control parameters to better deliver therapy to the brain. An MR-compatible PVDF hydrophone with a high sensitivity was constructed and characterized. The hydrophone was used to monitor microbubble-mediated ultrasound disruption of the blood-brain barrier in rats. Comparison of captured acoustic emissions with T1w and T2w images demonstrated that the hydrophone was able to detect differences in acoustic emissions in sonications producing different bioeffects. The results show promise for real-time monitoring of MRI-guided transcranial therapy.