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Abstract #1809

Three-Slice MR Pre-Treatment Temperature Mapping and Spherical Model Estimation for Accurate Localization of the Heating Focus Before High-Intensity Focused Ultrasound Treatment

Hsu-Hsia Peng1, Teng-Yi Huang2, Hsiao-Wen Chung3, Po-Cheng Chen4, Yu-Hui Ding4, Shiun-Ying Ju2, Yao-Hao Yang2, Wen-Yih Isaac Tseng5,6, Wen-Shiang Chen4,7

1Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan; 2Department of Electrical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan; 3Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan; 4Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Taipei, Taiwan; 5Center for Optoelectronic Biomedicine, Medical College of National Taiwan University, Taipei, Taiwan; 6Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan; 7Division of Medical Engineering Research, National Health Research Institutes, Miaoli, Taiwan


During HIFU treatment, the focus of ultrasound (US) is arranged to the targeting region determined in advance. In practical treatments, however, the focus might be deviated due to the complex path (tissue-bone interface or tissue-air interface) of US beams. For safety considerations, accurate localization of heating focus is important before performing HIFU treatment. In this study, a spherical model is proposed to estimate the real position of US focus. A low power pre-treatment experiment was performed on ex vivo porcine muscle. The estimated focus position was verified via magnetization transfer ratio images after a high power HIFU transmission.