Najat Salameh1, Line Souris1,
Laurent Marsac2, Jean-Franois Aubry3, Mathieu Pernot3,
Benjamin Robert2, Mathias Fink3, Luc Darrasse1,
Mickal Tanter3
1Imagerie par Rsonance Magntique
Mdicale et MultiModalit (UMR 8081), Universit Paris-Sud, CNRS, Orsay,
Iles-de-France, France; 2SuperSonic Imagine, Aix-en-Provence,
France; 3Institut Langevin, ESPCI ParisTech, CNRS UMR 7587 INSERM
U979, Paris, France
A
novel prototype for brain therapy with transcranial focused ultrasound is
presented here. The first part of this study showed that this new HIFU system
was fully MR-compatible. Secondly, we optimized a sequence for MR
thermometry, and followed the increase in temperature in a gel heated with
increasing power (from 125 to 500 Wac). Finally, we showed it is possible to
heat veal brains through a human skull at a high frequency and monitor the
heating process with MRI. After validation on cadaver heads, this work will
open new horizons to tumor brain therapy in animals and then in humans.
Keywords