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Abstract #1815

MR Guided High Intensity Focused Ultrasound for Tumor Ablation in Brain: Preliminary Results

Najat Salameh1, Line Souris1, Laurent Marsac2, Jean-Franois Aubry3, Mathieu Pernot3, Benjamin Robert2, Mathias Fink3, Luc Darrasse1, Mickal Tanter3

1Imagerie par Rsonance Magntique Mdicale et MultiModalit (UMR 8081), Universit Paris-Sud, CNRS, Orsay, Iles-de-France, France; 2SuperSonic Imagine, Aix-en-Provence, France; 3Institut Langevin, ESPCI ParisTech, CNRS UMR 7587 INSERM U979, Paris, France

A novel prototype for brain therapy with transcranial focused ultrasound is presented here. The first part of this study showed that this new HIFU system was fully MR-compatible. Secondly, we optimized a sequence for MR thermometry, and followed the increase in temperature in a gel heated with increasing power (from 125 to 500 Wac). Finally, we showed it is possible to heat veal brains through a human skull at a high frequency and monitor the heating process with MRI. After validation on cadaver heads, this work will open new horizons to tumor brain therapy in animals and then in humans.