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Abstract #1826

Hyperthermia Induced Gadodiamide Release from Thermosensitive Liposomes in Solid Tumors and Muscle Tissue

Michael Peller1, Martin Hossann2, Tungte Wang2,3, Steven Sourbron1, Lars H. Lindner2,3

1Institute of Clinical Radiology, University Hospital of Munich, Munich, Germany; 2Department of Internal Medicine III, University Hospital Munich; 3CCG-Hyperthermia, Helmholtz Zentrum Mnchen, German Research Center for Environmental Health, Germany

Purpose was to investigate the dynamics of mild temperature induced contrast agent release from phosphatidylglyc-eroglycerol containing thermosensitive liposomes with encapsulated Gd-DTPA-BMA (Gd-TSL) in tumor tissue. Tumor bearing mice were investigated at 1.5T after intravenous injection. The temperature induced release of contrast agent at 42C caused a fast and strong increase of T1-weighted signal. Immediately after i.v. injection heated tumor tissue was distinguishable from unheated tumor and muscle tissue. Unheated muscle tissue may thus be less affected by a potential anti tumor therapy based on TSL.