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Abstract #1848

Early Visualization of the Irreversible Electroporation Ablated Tissue Margin by Contrast Enhanced Imaging in Rodent Model

Yang Guo1, Yue Zhang1,2, Grace Nijm3, Alan Sahakian3, Guang-Yu Yang4, Reed Omary1,5, Andrew Larson1,5

1Department of Radiology, Northwestern University, Chicago, IL, United States; 2Department of Bioengineering , University of Illinois at Chicago, Chicago, IL, United States; 3Department of Electrical Engineering and Computer Science, Northwestern University, Evanston, IL, United States; 4Department of Pathology, Northwestern University, Chicago, IL, United States; 5Department of Biomedical Engineering , Northwestern University, Chicago, IL, United States

Electroporation involves targeted delivery of electrical pulses to permeabilize cell membranes, either reversible or irreversible. Irreversible electroporation (IRE), as a new tissue ablation technique, induces tissue necrosis due to permanent cell membrane defects. Assessment of tissue response to IRE may be critical. For our study, we demonstrate that inversion recovery prepared contrast enhancement imaging, with TI adjusted to null the signal intensity from the reversible zone, can visualize the IRE ablated tissue margin (differentiating reversible/irreversible zones) to provide an accurate prediction of ablation. This technique can early detect tissue response to IRE and might be helpful to guide further treatments.