Abstract #1875

On Possible Pitfalls in Working on SPIO Labelled Cells with 2D UTE Sequences

Clemens Diwoky¹, Andreas Reinisch², Florian Knoll¹, Bernhard Neumayer¹, Dirk Strunk², Rudolf Stollberger¹

¹Institute of Medical Engineering, Graz University of Technology, Graz, Austria; ²Stem Cell Research Unit, Dept. of Hematology, Univ. Clinic of Internal Medicine, Medical University of Graz, Graz, Austria

Within this study we outline some crucial points concerning the use of 2D UTE sequences for the cell detection based on differential images. We show that especially in regions of high iron density many artefacts caused by the pulse sequence yields to misinterpretations or wrong quantitative results. On the basis of an ectopic labelled cell population we discuss the artefacts caused by a common 2D UTE acquisition strategy with half-pulse excitation.