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Abstract #1894

Enzyme Mediated MRI Probes: Design, Synthesis and Relaxivity Behaviour of a Beta-Galactosidase Reporter

Eliana Gianolio1, Jebasingh Bhagavath Singh1, Markus Aswendt2, Francesca Arena1, Alessandro Barge3, Mathias Hoehn2, Silvio Aime1

1Chemistry IFM and Molecular Imaging Center, University of Torino, Torino, TO, Italy; 2In-vivo-NMR Laboratory, Max Planck Institute for Neurological Research, Cologne, Germany; 3Department of Drug Science and Technology, University of Torino, Torino, Italy

We report about the synthesis and the characterization of a Gd-DOTAgal derivative that has been proven to be a good -galactosidase expression reporter. It consists in a system that can undergo polymerization in the presence of Tyrosinase upon beta-gal activated cleavage of the tyr-gal bond.