Andrew Nencka1, Xiping Liu1, Joy
Jeseph1, Shi-Jiang Li1, Balaraman Kalyanaraman1
conventional T1 contrast agent, gadolinium-DTPA complex, does not cross the
blood brain barrier (BBB) in the absence of injury or tumor. Nitroxides
possess a single unpaired electron but generally do not cross the BBB. The compound we developed can cross the BBB
and provide MRI contrast in brain imaging by shortening the longitudinal
relaxation time (T1) of water protons (1).
Present study reports the progress of the development of a contrast
agent, 2,2,5,5- tetramethylpyrroline 1-oxide 3-ethyleneglycolcarboxylate
(CTPO-EG), which can cross the BBB and has significantly greater relaxivity.