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Abstract #1923

Silver Nanoparticles Functionalized with High Gadolinium Chelate Payload as Effective in Vivo T1-Brightening Contrast Agents

Lindsay Kathleen Hill1, Talha S. Siddiqui2, Dung Minh Hoang1, Susan Pun1, Marc Anton Walters2, Youssef Zaim Wadghiri1

1Radiology, NYU School of Medicine, New York, United States; 2Chemistry, New York University, New York, United States

In the research described here we designed a new silver multimodal nanoparticle containing GdDTPA and tested the effect of coligated polyethyleneglycol (PEG) chains on particle distribution, clearance and contrast enhancement. The resulting GdDTPA content, relaxivity and solubility were characterized in vitro and their biodistribution was assessed by abdominal MRI.