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Abstract #1939

Deterioration of Abstract Reasoning Ability in MCI and Alzheimer's Disease: Correlation with Local Gray Matter Volume Loss Using DARTEL VBM Analysis

Takashi Yoshiura1, Akio Hiwatashi1, Koji Yamashita1, Hironori Kamano1, Yukihisa Takayama1, Eiki Nagao1, Tuvshinjargal Dashjamts1, Hiroshi Honda1

1Department of Clinical Radiology, Kyushu University, Fukuoka, Japan

We estimated brain regions whose damages are responsible for the deterioration in abstract reasoning ability measured by Ravenfs colored progressive matrices (CPM) in 37 patients with Alzheimerfs disease (AD) (n=19) and mild cognitive impairment (MCI) (n=18) using VBM with non-linear registration based on DARTEL algorithm. A multiple regression analysis was used to map the regions where gray matter volumes were correlated with CPM scores. Significant correlations were seen in 14 regions with the strongest correlation in the left middle frontal gyrus. Results suggested that damages of multiple regions are responsible for deterioration of abstract reasoning ability in AD and MCI.