Abstract #1949

A Study of APOE and Cerebral Perfusion in Adult Offspring of Patients with Alzheimer's Dementia Using Dynamic Susceptibility Contrast MRI

Rachel DiAnne McKinsey¹, Zhifei Wen¹, Alan McMillian¹, Beth Meyerand¹, Sterling Johnson², Sean Fain^1,3, Cindy Carlsson²

¹Medical Physics, University of Wisconsin-Madison, Madison, WI, United States; ²GRECC, Veteran Administration Hospital, Madison, WI, United States; ³Radiology, University of Wisconsin-Madison, Madison, WI, United States

APOE and vascular dysfunction are associated with increased risk of AD. Changes in perfusion have been identified in APOE carriers verse non-carriers. The application of DSC perfusion with intravenous gadolinium contrast injection to investigate perfusion changes in AD has the ability to provide CBF, CBV, and MTT perfusion maps. We investigated the ability of DSC MRI to measure CBV, CBF, and MTT changes in non-demented children with increased risk for AD due to one or more risk factors: APOE and/or family history.