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Abstract #1949

A Study of APOE and Cerebral Perfusion in Adult Offspring of Patients with Alzheimer's Dementia Using Dynamic Susceptibility Contrast MRI

Rachel DiAnne McKinsey1, Zhifei Wen1, Alan McMillian1, Beth Meyerand1, Sterling Johnson2, Sean Fain1,3, Cindy Carlsson2

1Medical Physics, University of Wisconsin-Madison, Madison, WI, United States; 2GRECC, Veteran Administration Hospital, Madison, WI, United States; 3Radiology, University of Wisconsin-Madison, Madison, WI, United States

APOE and vascular dysfunction are associated with increased risk of AD. Changes in perfusion have been identified in APOE carriers verse non-carriers. The application of DSC perfusion with intravenous gadolinium contrast injection to investigate perfusion changes in AD has the ability to provide CBF, CBV, and MTT perfusion maps. We investigated the ability of DSC MRI to measure CBV, CBF, and MTT changes in non-demented children with increased risk for AD due to one or more risk factors: APOE and/or family history.