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Abstract #1958

Resting-State FMRI Contributes to Differentiate Patients with Dementia with Lewy Bodies from Those with Alzheimer's Disease

Barbara Basile1, Mara Cercignani1, Laura Serra2, Roberta Perri3, Camillo Marra4, Lucia Fadda3, Carlo Caltagirone3,5, Marco Bozzali2

1Neuroimaging Laboratory, Santa Lucia Foundation, Rome , Italy, Italy; 2Neuroimaging Laboratory, Santa Lucia Foundation, Rome, Italy, Italy; 3Clinical and Behavioural Neurology Laboratory, Santa Lucia Foundation, Rome, Italy, Italy; 4Department of Neurosciences, Catholic University of Rome, Roma, Italy, Italy; 5Department of Neurosciences , University of Torvergata, Rome, Italy, Italy

Resting-state fMRI was used to investigate changes of functional connectivity (FC) within specific resting-state networks (RSNs) in the presence of Alzheimer's disease (AD) and dementia with Lewy Bodies (DLB) as compared to normal aging. Using ICA analysis, we identified 10 RSNs across subjects. AD patients revealed reduced FC in the posterior cingulate, within the default-mode-network. Conversely, DLB patients showed reduced FC in occipital areas, within the visual network. These findings respectively account for brain disconnection between medial temporal lobes and other association cortexes in the development of AD symptoms, and for occipital abnormalities potentially responsible for visual hallucinations in DLB.