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Abstract #1969

Regional and Global Cerebral Blood Flow Is Reduced in Patients with Post-Stroke Dementia

Jiabao He1, Michael J. Firbank2, Rajesh N. Kalaria2, Baldev Singh2, Paul Danson2, John O'Brien2, Andrew M. Blamire1

1Newcastle MR Centre and Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; 2Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom

Stroke is one of the most important risk factors for dementia. In stroke survivors who do not have immediate, severe cognitive impairment, the risk of developing dementia is significantly increased. Stroke may also exacerbate or trigger the development of neurodegenerative pathology. Small vessel vascular effects may be an important factor in neurodegeneration. We compared CBF in post-stroke patients with and without cognitive decline, patients with Alzheimers disease and healthy controls. Regional and global deficits in CBF were found in patients with post-stroke dementia resembling patterns of change in AD patients, while cognitively intact post-stroke patients had normal CBF.