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Abstract #1988

A Population-Based Template for High-Dimensional Normalization of Postmortem Human Brains from Elderly Subjects

Robert John Dawe1, David A. Bennett2, Julie A. Schneider2, Konstantinos Arfanakis1

1Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States; 2Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, United States

Postmortem MRI of the human brain offers several advantages over in vivo imaging. For example, histological analysis can be performed following the MR scan, allowing for verification of imaging findings and testing of new MRI diagnostic techniques. Spatial transformation of individual postmortem brain MRI volumes to a common reference would facilitate voxel-based investigations, which would provide information throughout the brain in a timely manner and without user bias, in contrast to ROI-based analyses. In this work, population-based methods were used to create an MRI template that is suitable for high dimensional spatial normalization of postmortem human cerebral hemispheres.