Meeting Banner
Abstract #2000

Effects of Sex and Age on Regional Frontal Lobe Gray Matter Distribution

Vanessa Anne Sluming1,2, Andrew Mayes3, Iain D. Wilkinson4, Charles Romanowski4, Enis Cezayirli5, Patricia E. Cowell6

1School of Health Sciences, University of Liverpool, Liverpool, Merseyside, United Kingdom; 2Magnetic Resonance and Image Analysis Research Centre, University of Liverpool, Liverpool, Merseyside, United Kingdom; 3School of Psychology, University of Manchester, Manchester, United Kingdom; 4Academic Department of Radiology, University of Sheffield, United Kingdom; 5Department of Anatomy, University of Celal Bayar , Turkey; 6Department of Human Communication Sciences, University of Sheffield, United Kingdom

VBM analysis of grey matter distribution within the healthy adult brain was undertaken, in a sample of 31 males and 35 females (age range: 20-72 years) to investigate sex differences in the effect of brain ageing. Data were analysed using a full factorial analysis (2x2x2). There were no significant sex by age effects. Within sex regression analyses revealed that females showed age related GM decrements within several frontal regions tending medially, whereas males sowed age related decrements in bilateral structures including IFG (BA44/45). These findings are discussed.