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Abstract #2027

Mapping the Development of the Human Connectome

Patric Hagmann1, Olaf Sporns2, Stephan Gerhard3, Rudolph Pienaar4,5, Jean-Philippe Thiran3, Leila Cammoun3, Neel Madan6, P Ellen Grant4,5

1Department of Radiology, CHUV-UNIL, Lausanne, VD, Switzerland; 2Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, United States; 3Signal Processing Laboratory 5, EPFL, Lausanne, VD, Switzerland; 4Division of Newborn Medicine and Department of Radiology, Childrens Hospital Boston, Boston, MA, United States; 5Athinoula A. Martinos Center for Biomedical Imaging, MGH-Harvard, Boston, MA, United States; 6Department of Radiology, MGH-Harvard, Boston, MA, United States

From birth to early adulthood the brain undergoes dramatic modifications resulting in network development and optimization. In the present study we investigate the development of the human connectome but measuring myelination trajectories of individual connections over the entire brain structural network using high b-value diffusion imaging and tractography. We found significant changes in several network measures that support increased integration and efficiency. We also observe that the network doesnt myelinate at a uniform rate but with different myelination speeds dependant on the type of cortex.