Patric Hagmann1, Olaf Sporns2,
Stephan Gerhard3, Rudolph Pienaar4,5, Jean-Philippe
Thiran3, Leila Cammoun3, Neel Madan6, P
Ellen Grant4,5
1Department of Radiology, CHUV-UNIL,
Lausanne, VD, Switzerland; 2Department of Psychological and Brain Sciences,
Indiana University, Bloomington, IN, United States; 3Signal
Processing Laboratory 5, EPFL, Lausanne, VD, Switzerland; 4Division
of Newborn Medicine and Department of Radiology, Childrens Hospital Boston,
Boston, MA, United States; 5Athinoula A. Martinos Center for
Biomedical Imaging, MGH-Harvard, Boston, MA, United States; 6Department
of Radiology, MGH-Harvard, Boston, MA, United States
From
birth to early adulthood the brain undergoes dramatic modifications resulting
in network development and optimization. In the present study we investigate
the development of the human connectome but measuring myelination
trajectories of individual connections over the entire brain structural
network using high b-value diffusion imaging and tractography. We found
significant changes in several network measures that support increased
integration and efficiency. We also observe that the network doesnt
myelinate at a uniform rate but with different myelination speeds dependant
on the type of cortex.
Keywords