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Abstract #2048

Impaired Neurodevelopmental Outcome Associated with Increased White Matter Chol/Cr in Preterm Infants

David Price1, Giles Simon Kendall2, Alan Bainbridge1, Samantha Johnson2, Cornelia Hagmann2, Roxanna Gunny3, Xavier Golay4, Ernest B. Cady1, Nicola Jane Robertson2, Enrico De Vita5

1Medical Physics & Bio-Engineering, UCL Hospitals NHS Foundation Trust, London, United Kingdom; 2Academic Neonatology, EGA UCL Institute for Women's Health, London, United Kingdom; 3Neuroradiology, Great Ormond Street Hospital for Children; 4Institute of Neurology, University College London; 5Lysholm Department of Neuroradiology, UCL Hospitals NHS Foundation Trust, London, United Kingdom

Infants born prematurely have a higher incidence of neurodevelopmental disorders. Diffuse white matter injury is the commonest MR finding in preterm infants, and has been described qualitatively and quantitatively; the clinical correlate of diffuse white matter injury is currently unknown. In the current study raised Cho/Cr and Lac/Cr, and reduced Naa/Cho were significantly associated with composite motor outcome at 12 months corrected age, and accounted for by significant associations with gross motor development. The raised choline could be attributed to delayed myelination, astrogliosis; the raised Lac/Cr suggests impaired oxidative phosphorylation, and the reduced Naa is in keeping with neuronal loss.