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Abstract #2070

High Resolution Magnetization Transfer Imaging at 7T : Detection of Cortical Lesions in MS Patient

Olivier E. Mougin1, Jennifer Dixon1, Ian Donaldson2, Emma Tallantyre2, Nikos Evangelou2, Penny A. Gowland1

1Sir Peter Mansfield Magnetic Resonance Centre, School of Physics & Astronomy,University of Nottingham, Nottingham, Nottinghamshire, United Kingdom; 2Institute of Neuroscience, Nottingham, Nottinghamshire, United Kingdom

This study aims to detect cortical lesions in MS patients. High resolution MTR scans (0.5mm isotropic, as well as 0.35mm in plane resolution) have been acquired at 7T using a novel imaging sequence. The MTR contrast has been compared between white matter and grey matter, showing a greater grey matter (GM) / white matter (WM) contrast to noise ratio at 7T, providing a good delineation of WM and GM lesions at high resolution with the MTR contrast. The sequence is being used to study changes in the cortex of MS patients.