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Abstract #2082

Corpus Callosum Atrophy and Diffusion Abnormalities in Clinically Isolated Syndrome Revealed by Diffusion Tensor Tractography

Fuchun Lin1, Chunshui Yu2, Yaou Liu2, Hao Lei1

1Wuhan Institute of Physics & Mathematics, The Chinese Academy of Sciences, Wuhan, Hubei, China; 2Department of Radiology, Xuanwu Hospital of Capital Medical University, Beijing, China

Diffusion tensor based group tractography was used to determine the corpus callosum (CC) integrity in clinically isolated syndrome (CIS). Compared to the healthy subjects, the CIS patients had significantly reduced midsagittal CC area, and significantly higher MD, λ 1, λ 23 and significantly lower FA in the entire CC. Moreover, the average FA of the normal-appearing CC of the CIS patients correlated negatively with the whole-brain lesion load while the other three diffusion indices correlated with the lesion load positively. These results suggested that both the morphology and the microstructure of the CC appear to be damaged at the stage of CIS.