Junqian Xu1, Robert T. Naismith1, Nhial Tutlam1, Kathryn M. Trinkaus2, Sheng-Kwei Song3, Anne Cross1
1Neurology, Washington University in St. Louis, St. Louis, MO, United States; 2Biostatistics, Washington University in St. Louis, St. Louis, MO, United States; 3Radiology, Washington University in St. Louis, St. Louis, MO, United States
We studied 70 remote optic neuritis (ON) patients using the previously described high-resolution reduced field-of-view optic nerve diffusion tensor imaging protocol at 3 T. Radial diffusivity (RD) strongly correlated with visual functional assessments, retinal nerve fiber layer thickness, and visual evoked potential. RD also discriminated nerves with normal recovery from those with mild visual impairment, and those with mild impairment from profound visual loss. In addition, RD differentiated healthy controls from both the clinically affected nerves and unaffected fellow nerves after ON. RD differentiated all categories of 5% contrast sensitivity (CS) outcomes, and all categories of Pelli-Robson CS with the exception of normal recovery from mildly affected.