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Abstract #2103

Cognitive Impairment in Early Multiple Sclerosis Related to Metabolic Impairment in Cerebellum

Wafaa Zaaraoui1, Franoise Reuter1, Audrey Rico1, Irina Malikova1, Elisabeth Soulier1, Patrick Viout1, Yann Le Fur1, Sylviane Confort-Gouny1, Patrick J. Cozzone1, Jean Pelletier1, Jean-Philippe Ranjeva1, Bertrand Audoin1

1Facult de Mdecine, CRMBM UMR CNRS 6612, Marseille, France

While metabolic changes and cognitive impairment are known to be present in multiple sclerosis (MS) from the earliest stage of the disease, no exhaustive examinations have been performed to assess potential relationships between metabolite levels and cognitive status. Our study aimed to investigate whether magnetic resonance spectroscopic markers in normal appearing brain tissues are related to cognitive status in multiple sclerosis.