Madeleine Hodgson1, Cornelia Laule1,2, Irene Vavasour1,2, Burkhard Mdler1, Alex MacKay1,2
1Physics, University of British Columbia, Vancouver, British Columbia, Canada; 2Radiology, University of British Columbia, Vancouver, British Columbia, Canada
Little is known about the pathological evolution of acute MS lesions. Using 1H-MRS one can measure changes in metabolites such as n-acetyl-aspartate (NAA), which may become altered in MS. We used 1H-MRS and water proton T1 measurements to investigate the time-course of biochemical changes occurring in new MS lesions. Multi-voxel 1H-MRS data was acquired monthly from 20 Relapsing-Remitting MS subjects. Metabolite and water proton T1 changes for the same volume were investigated Lesions exhibited a significant decrease in NAA and a significant increase in mean T1, compared to normal appearing white matter, 2 months before lesion appearance on conventional imaging.