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Abstract #2106

1H-MRS and Water Proton T1 Investigations of New Lesions in Relapse Remitting Multiple Sclerosis

Madeleine Hodgson1, Cornelia Laule1,2, Irene Vavasour1,2, Burkhard Mdler1, Alex MacKay1,2

1Physics, University of British Columbia, Vancouver, British Columbia, Canada; 2Radiology, University of British Columbia, Vancouver, British Columbia, Canada

Little is known about the pathological evolution of acute MS lesions. Using 1H-MRS one can measure changes in metabolites such as n-acetyl-aspartate (NAA), which may become altered in MS. We used 1H-MRS and water proton T1 measurements to investigate the time-course of biochemical changes occurring in new MS lesions. Multi-voxel 1H-MRS data was acquired monthly from 20 Relapsing-Remitting MS subjects. Metabolite and water proton T1 changes for the same volume were investigated Lesions exhibited a significant decrease in NAA and a significant increase in mean T1, compared to normal appearing white matter, 2 months before lesion appearance on conventional imaging.