In-Young Choi1,2, Sang-Pil Lee1,3,
Sharon G. Lynch4
1Hoglund Brain Imaging Center,
University of Kansas Medical Center, Kansas City, KS, United States; 2Department
of Neurology, Molecular & Integrative Physiology, University of Kansas
Medical Center, Kansas City, KS, United States; 3Department of
Molecular & Integrative Physiology, University of Kansas Medical Center,
Kansas City, KS, United States; 4Department of Neurology,
University of Kansas Medical Center, Kansas City, KS, United States
Oxidative
stress has been implicated in multiple sclerosis (MS), a chronic inflammatory
disease with the presence of a neurodegenerative process particularly in
progressive MS. However, the effects
of oxidative stress in MS have not been well described in the living human
brain. In this study, we measured the cerebral GSH levels in the patients
with secondary progressive MS (SPMS) using doubly selective multiple quantum
GSH CSI. The GSH levels were significantly lower in the SPMS patients
compared with those in the age- and gender-matched healthy controls,
indicating the presence of increased oxidative stress in the absence of
measurable inflammation.
Keywords