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Abstract #2115

Relative Recirculation (RR): A Potential Tool for Monitoring Blood-Brain Barrier Disruption in Secondary Progressive Multiple Sclerosis

Andrea Kassner1,2, Igor Sitartchouk1, Rebecca E. Thornhill1,2, Timothy J. Carroll3, Chaitali Mulay4, Richard Aviv1,4

1Medical Imaging, University of Toronto, Toronto, Ontario, Canada; 2Physiology and Experimental Medicine, Hospital for Sick Children, Toronto, Ontario, Canada; 3Radiology, Northwestern University, Chicago, IL, United States; 4Neuroradiology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system. While blood-brain barrier (BBB) disruption associated with relapsing-remitting MS is readily identified using gadolinium-enhanced T1-weighted MRI, these MRI markers lack the sensitivity required for monitoring secondary progressive MS. Relative recirculation (rR), a parameter extracted from dynamic susceptibility contrast (DSC) data, can delineate BBB disruption in patients with acute ischemic stroke. Relative recirculation was measured from DSC perfusion data obtained from 19 patients with secondary progressive MS. The average lesion rR was significantly greater than in normal appearing white matter and shows potential for monitoring secondary progressive MS.