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Abstract #2126

Voxelwise Analysis of Pelizeaus-Merzbacher Disease in 17 Genetically Proven Cases Using Diffusion Tensor Imaging

Onur Ozyurt1, Alp Dincer2, Zuhal Yapici3, Cengiz Yalcinkaya4, Mefkure Eraksoy3, Cengizhan Ozturk1

1Bogazici University, Biomedical Engineering Institute, Istanbul, Turkey; 2Acibadem University, School of Medicine, Department of Radiology; 3Istanbul University, Istanbul Faculty of Medicine, Department of Neurology; 4Istanbul University, Cerrahpasa Medical Faculty, Department of Neurology

In this study, tract based spatial statistics (TBSS) approach is used for the investigation of Pelizeaus-Merzbacher Disease (PMD), which is a rare X-linked disease characterized by defective central nervous system myelination due to a mutation in the proteolipid protein 1 gene.