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Abstract #2130

Relationship Between Serum Inflammatory Markers, Regional Brain Volumes, and Perfusion in Older Diabetic Subjects

Peng Zhao1, Vera Novak1, Kun Hu1, Medha Munshi1, David Alsop2, Amir Abduljalil3, Peter Novak4

1Gerontology, Beth Israel Deaconess Medical Center, Boston, MA, United States; 2Radiology, Beth Israel Deaconess Medical Center, Boston, MA, United States; 3Radiology, Ohio State University, Columbus, OH, United States; 4Neurolgoy, University of Massachusetts Medical School, Worcester, MA, United States

Type 2 DM is a major risk factor for both large and small vessel atherosclerosis, stroke, and vascular dementia. Hyperglycemia is a common mechanism of endothelial dysfunction and neuronal cell damage. Microvascular disease manifests as white matter hyperintesities on MRI, regional atrophy and functional decline. Inflammation further affects microcirculatory regulation and contributes to arteriolosclerosis. We investigated the effects of inflammation on regional perfusion and neurodegenerative changes in grey and white matter on MRI. Inflammatory markers had different effects on regional brain volumes. sICAM was associated with atrophy across all regions in the DM group, with the most significant effects in the frontal and parietal regions. In the control group, regional perfusion on both sides in the parietal lobe is positively correlated with sICAM, and perfusion in the right occipital lobe is positive with sVCAM. Associations between regional brain volumes and other inflammatory markers were not prominent. Frontal and parietal regions with high energy demands are more vulnerable to the effects of DM in the brain.