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Abstract #2138

The Effect of Systemic Depletion of Natural Killer Cells in an EAE Mouse Model of Multiple Sclerosis Examined by Magnetic Resonance Imaging and Bioluminescence Imaging

Gregory Harrison Turner1, Junwei Hao2, Ruolan Liu2, Wenhua Piao2, Timothy L. Vollmer3, Rong Xiang4, Antonio La Cava5, Denise I. Campagnolo2, Luc Van Kaer6, Fu-Dong Shi2

1Keller Center for Imaging Innovation, Barrow Neurological Institute, Phoenix, AZ, United States; 2Neurology, Barrow Neurological Institute, Phoenix, AZ, United States; 3Neurology, University of Colorado Denver School of Medicine, Aurora, CO, United States; 4Medicine, Nankai University, Tianjin, China; 5Medicine, University of California Los Angeles, Los Angeles, CA, United States; 6Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, United States

Natural killer (NK) cells of the innate immune system can profoundly impact the development of adaptive immune responses against foreign invaders, as well as self-antigens. In this study a combination of in vivo MRI and bioluminescence imaging was used to investigate effects of systemic depletion of NK cells on lesion development in an experimental autoimmune encephalomyelitis (EAE) mouse model of multiple sclerosis. The results of this study suggest organ-specific activity of NK cells on the magnitude of CNS inflammation.