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Abstract #2144

Brain Matter Corrected Quantification of Phosphomono- And Phosphodiesters in the Brain of Patients with Schizophrenia

Wolfgang Weber-Fahr1, Mathias Zink2, Andreas Meyer-Lindenberg2, Monika Uhrig1, Nuran Tunc-Skarka1, Mareen Hoerst1, Helga Welzel-marquez1, Alexander Sartorius2, Gabriele Ende1

1Neuroimaging, Central Institute of Mental Health, Mannheim, NA, Germany; 2Dept. Psychiatry, Central Institute of Mental Health, Mannheim, NA, Germany

A 3D-whole head RINEPT sequence was used together with point-spread function corrected tissue segmentation for robust absolute quantification of spectral edited Phosphomono- and diester-signals in the brains of schizophrenic patients and controls. The corrected metabolite concentrations show a significant reduction of Phosphocholine and Glycerophosphocholine (GPC) in the basal ganglia and thalamus of schizophrenic patients compared to controls. GPC was also significantly lower in the cerebellum while Phosphorylethanolamine showed a trend for lower concentration in patients in the frontal region.