Abstract #2147

fMRI and Connectivity Effects of Electro-Convulsive Therapy (ECT) in Depressed Patients

Erik B. Beall¹, Mark J. Lowe¹, Michael D. Phillips¹, Steve Jones¹, Pallab K. Bhattacharyya¹, David Muzina²

¹Radiology, Cleveland Clinic, Cleveland, OH, United States; ²Psychiatry, Cleveland Clinic, Cleveland, OH, United States

ECT is a safe and effective treatment for depression. However its mechanisms have not been studied with the BOLD effect in a pre- and post-ECT fMRI and connectivity study. We present preliminary results that show reduced activation and connectivity in response to working memory and affective tasks.