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Abstract #2147

fMRI and Connectivity Effects of Electro-Convulsive Therapy (ECT) in Depressed Patients

Erik B. Beall1, Mark J. Lowe1, Michael D. Phillips1, Steve Jones1, Pallab K. Bhattacharyya1, David Muzina2

1Radiology, Cleveland Clinic, Cleveland, OH, United States; 2Psychiatry, Cleveland Clinic, Cleveland, OH, United States

ECT is a safe and effective treatment for depression. However its mechanisms have not been studied with the BOLD effect in a pre- and post-ECT fMRI and connectivity study. We present preliminary results that show reduced activation and connectivity in response to working memory and affective tasks.