Tzu-chen Yeh1,2, Chih-Ying Lin2,
Cheng-Wen Ko3, Ton-Ping Su4, Wan-Yuo Guo5,
Jen-Chuen Hsieh2, Low-Ton Ho1
1Department of Medical Research and
Education, Taipei Veterans General Hospital, Taipei, Taiwan, Taiwan; 2Institute
of Brain Science, National Yang-Ming University, Taipei, Taiwan, Taiwan; 3Department
of Computer Science and Engineering, National Sun Yat-sen University,
Kaohsiung, Taiwan, Taiwan; 4Department of Psychiatry, Taipei
Veterans General Hospital, Taipei, Taiwan, Taiwan; 5Department of
Radiology, Taipei Veterans General Hospital, Taipei, Taiwan, Taiwan
The
spatial template of default-mode network (DMN) has been constructed and shown
precuneus/posterior cingulate areas (PC, Brodmann area 31) with highest
reproducibility in 60 normal subjects. High resting metabolic rate of DMN was
implied by previous deoxy-glucose positron emission tomography. In this study
of affective disorders (bipolar and major depressive disorders),
bioenergetics of Brodmann area 24 and DMN was probed by total creatine using
real-time localized image-guided proton magnetic resonance spectroscopy
(ig-HMRS) and LCModel quantification. As compared to affective disorders,
higher metabolism of PC (representing DMN) in normal subjects was supported
by higher total creatine concentration.
Keywords