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Abstract #2156

Impaired Default-Mode Networks of Affective Disorders: Evidences of Image-Guided Proton MRS

Tzu-chen Yeh1,2, Chih-Ying Lin2, Cheng-Wen Ko3, Ton-Ping Su4, Wan-Yuo Guo5, Jen-Chuen Hsieh2, Low-Ton Ho1

1Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan, Taiwan; 2Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan, Taiwan; 3Department of Computer Science and Engineering, National Sun Yat-sen University, Kaohsiung, Taiwan, Taiwan; 4Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan, Taiwan; 5Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan, Taiwan

The spatial template of default-mode network (DMN) has been constructed and shown precuneus/posterior cingulate areas (PC, Brodmann area 31) with highest reproducibility in 60 normal subjects. High resting metabolic rate of DMN was implied by previous deoxy-glucose positron emission tomography. In this study of affective disorders (bipolar and major depressive disorders), bioenergetics of Brodmann area 24 and DMN was probed by total creatine using real-time localized image-guided proton magnetic resonance spectroscopy (ig-HMRS) and LCModel quantification. As compared to affective disorders, higher metabolism of PC (representing DMN) in normal subjects was supported by higher total creatine concentration.