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Abstract #2171

Parametric Response Map as an Imaging Biomarker to Distinguish Progression from Pseudoprogression in High Grade Gliomas

Christina Tsien1, Craig J. Galban1, Thomas L. Chenevert1, Timothy D. Johnson1, Daniel A. Hamstra1, Pia C. Sundgren1, Larry Junck1, Charles R. Meyer1, Alnawaz Rehemtulla1, Theodore Lawrence1, Brian D. Ross1

1University of Michigan, Ann Arbor, MI, United States

We have developed a reliable method for distinguishing true progression from pseudoprogression by quantifying on a voxel-wise basis therapeutic-associated hemodynamic alterations in patients with high grade glioma. The parametric response map of rCBV (PRMrCBV) at week 3 during chemoradiation is shown to be a potential early imaging biomarker of response that may be helpful in distinguishing pseudoprogression from true progression in patients with high grade glioma.