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Abstract #2173

Dynamic Contrast Enhanced and Susceptibility Based CBV Measurements Perform Equally in Grading of Cerebral Gliomas

Muftah Ahmed Manita1, Paul Morgan2, Keith Robson3, Timothy Jaspan3, Dorothee P. Auer1

1Academic Radiology, University of Nottingham, Nottingham, United Kingdom; 2Radiology & Radiological Science, Medical University of South Carolina, United States; 3Nottingham University Hospital, United Kingdom

Perfusion MRI DSC (T2*) has shown added values in glioma tumour differentiation with rCBVmax is the best performing metrics obtained from dynamic susceptibility contrast technique (DSC). However, this technique is susceptible to blood leak that results in rCBV overestimation. T1 MRI perfusion (DCE) is not susceptible to vascular disruption. Nineteen patients with low and high grade glioma underwent MR perfusion (T1 and T2*) was analysed with Java image software. Significant difference (P=0.000) with excellent correlation (0.81) between the two tumour grades in both techniques with accuracy of 100%. T1 based DCE is robust technique to follow postoperative cases.