Abstract #2204

Finding Early Prognostic Marker from 3D 1H-MRSI and Diffusion Tensor Imaging for Newly-Diagnosed GBM Patients Receiving Radiation, Temozolomide and PKC Inhibitor

Ilwoo Park^1,2, Adam Elkhaled², Achuta Kadambi², Inas Khayal², Nicholas Butowski³, Susan M. Chang³, Sarah J. Nelson^1,2

¹Joint Graduate group in Bioengineering, University of California San Francisco/Berkeley, San Francisco, CA, United States; ²Surbeck Laboratory of Advanced Imaging, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States; ³Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, United States

The purpose of this study was to use 3D ¹H MR Spectroscopic Imaging (MRSI) and diffusion tensor imaging (DTI) to develop early prognostic markers for GBM patients undergoing radiation, temozolomide and PKC inhibitor. Twenty-nine patients with newly diagnosed GBM were examined using a 3T MR scanner. Conventional anatomical imaging parameters could not distinguish between progression groups at baseline or 1 month. Parameters derived from MRSI and DTI provided information at baseline and early follow-up examinations that may be valuable in predicting the time-to-progression for patients with GBM.