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Abstract #2209

5 Year Longitudinal Mri Follow-Up and 1H Single Voxel Mrs in 13 Patients with Gliomatosis Treated with Temodal, Radiotherapy and Antiangiogenic Therapy.

Jean-Marc Constans1,2, Franois Kauffmann3, Gabriela Hossu4, Weibei Dou5, Jean-Michel Derlon6, Emmanuelle Lechapt-Zalcmann7, Samuel Valable8, Jean-Sebastien Guillamo9,10

1MR Unit, CHU de CAEN, CAEN, Normandy, France; 2CERVOxy, Cyceron- CI-NAPS- CNRS , CAEN, Normandy, France; 3LMNO- UMR 6139, CNRS, CAEN, France; 4UMR 947, CIC-IT et INSERM, Nancy, France; 5Electronic, Tsinghua University, Beijing, China; 6CHU de Caen, CAEN, France; 7CHU de Caen, Caen, France; 8Cyceron CINAPS CNRS UMR 6232, CAEN, France; 9CHU CAEN, France; 10CERVOxy, Cyceron CNRS CI-NAPS, CAEN, France

MRS with Cho/Cr, mI/Cr and NAA/Cr ratios, could be more sensitive than MRI and could, in some cases, be predictive of worsening in gliomatosis follow-up. These spectroscopic changes occurred well before clinical deterioration. There is a large variability, but repetition and modelisation of spectroscopic measurements during longitudinal follow-up could allow us to diminish it and to improve gliomatosis prognostic evaluation.