MR Biomarker Profile for Infiltrative Tumor Region in Malignant Glioma

Radhika Srinivasan¹, Joanna J. Phillips¹, Gabriela Bourne¹, Alvin Au¹, Soonmee Cha¹, Susan Chang¹, Sarah J. Nelson¹

This study addresses the inability of conventional imaging to delineate infiltrative tumor regions, which causes the tumor to recur within the treatment volume. These regions have normal cellularity due to diffusely infiltrating cells and cannot be located based on increased cellularity with choline and ADC. To define an MR profile of an infiltrative tumor region HR-MAS spectroscopy of image-guided biopsies in newly diagnosed and recurrent GBM were analyzed and evaluated relative their spatial location within the tumor, pathological measures of its paired sample and diffusion measures derived from the biopsy location. These results will be presented and discussed.