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Abstract #2216

Initial Experience with Ferumoxytol Dynamic Susceptibility MRI in Human Brain at 3T and 7T

Jeffrey Moses Njus1, Edit Dosa2, Seymur Gahramanov2, John W. Grinstead3, Xin Li1, Charles S. Springer, Jr. 1, Edward A. Neuwelt2, William D. Rooney1

1Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States; 2Department of Neurology, Oregon Health & Science University, Portland, OR, United States; 3Siemens Medical Solutions, Portland, OR, United States

MRI DSC techniques offer an efficient way to characterize brain perfusion properties. However, the use of low-molecular weight gadolinium based contrast agents (Gd) can introduce a significant confound into standard DSC analysis if extravasation is extensive; as often is the case for brain tumors. The purpose of this study was to investigate the use of an ultra-small paramagnetic iron oxide (USPIO) compound to estimate brain tumor blood volume in human subjects. To accomplish this goal, DSC acquisitions were performed using both Gd and USPIO based contrast agents in eleven human subjects at 3T and 7T.