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Abstract #2221

Differing Fractional Anisotropy Changes in Grey Matter and White Matter in Early Ischemic Stroke

Mohamed Mustafa Hirji1,2, Ashley D. Harris, 2,3, Robert K. Kosior, 2,4, Cheryl R. McCreary, 2,5, Richard Frayne2,5

1University of Calgary, Calgary, Alberta, Canada; 2Seaman Family MR Research Centre, Alberta Health Services, Calgary, Alberta, Canada; 3School of Psychology & Cardiff University Brain Research Imaging Centre, Cardiff University, Cardiff, Wales, United Kingdom; 4Biomedical Engineering, University of Calgary, Calgary, Alberta, Canada; 5Radiology & Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada

We characterise the fractional anisotropy (FA) changes in ischemic stroke. Diffusion tensor images of 13 patients were obtained within 26 hours of stroke (acutely) and >21 days later (follow-up). FA and eigenvalues were measured in freehand regions of interest (ROIs); anatomically-matched contralateral ROIs were used for control. Acutely, FA increased in gray matter (GM) but not in white matter (WM); the eigenvalue reductions were unbalanced in GM, but balanced in WM. At follow-up, FA decreased in both GM and WM with the eigenvalue changes similar in both GM and WM. Our results give insight into microstructural changes in stroke.